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If you’re looking for a simple syrup substitute, there are three favorites you probably have right in your home: honey, maple syrup and agave. For honey or agave, add warm water to them, to help turn the mix to syrup. You can also use a sweet, juicy fruit, like an orange. The juice is usually sweet enough to substitute for syrup. So, when you’re looking for a simple syrup substitute for cocktails, look no further than your kitchen.